Partial linear single-index models with additive distortion measurement errors

We study partial linear single-index models (PLSiMs) when the response and the covariates in the parametric part are measured with additive distortion measurement errors. These distortions are modeled by unknown functions of a commonly observable confounding variable. We use the semiparametric profile least-squares method to estimate the parameters in the PLSiMs based on the residuals obtained from the distorted variables and confounding variable. We also employ the smoothly clipped absolute deviation penalty (SCAD) to select the relevant variables in the PLSiMs. We show that the resulting SCAD estimators are consistent and possess the oracle property. For the non parametric link function, we construct the simultaneous confidence bands and obtain the asymptotic distribution of the maximum absolute deviation between the estimated link function and the true link function. A simulation study is conducted to evaluate the performance of the proposed methods and a real dataset is analyzed for illustration.     

Maternal union instability and childhood mortality risk in the Global South, 2010–14

Efforts to improve child survival in lower-income countries typically focus on fundamental factors such as economic resources and infrastructure provision, even though research from post-industrial countries confirms that family instability has important health consequences. We tested the association between maternal union instability and children’s mortality risk in Africa, Latin America and the Caribbean, and Asia using children’s actual experience of mortality (discrete-time probit hazard models) as well as their experience of untreated morbidity (probit regression). Children of divorced/separated mothers experience compromised survival chances, but children of mothers who have never been in a union generally do not. Among children of partnered women, those whose mothers have experienced prior union transitions have a higher mortality risk. Targeting children of mothers who have experienced union instability—regardless of current union status—may augment ongoing efforts to reduce childhood mortality, especially in Africa and Latin America where union transitions are common.     

Adaptive designs for single‐arm phase II trials in oncology

Clinical phase II trials in oncology are conducted to determine whether the activity of a new anticancer treatment is promising enough to merit further investigation. Two‐stage designs are commonly used for this situation to allow for early termination. Designs proposed in the literature so far have the common drawback that the sample sizes for the two stages have to be specified in the protocol and have to be adhered to strictly during the course of the trial. As a consequence, designs that allow a higher extent of flexibility are desirable. In this article, we propose a new adaptive method that allows an arbitrary modification of the sample size of the second stage using the results of the interim analysis or external information while controlling the type I error rate. If the sample size is not changed during the trial, the proposed design shows very similar characteristics to the optimal two‐stage design proposed by Chang et al. (Biometrics 1987; 43:865–874). However, the new design allows the use of mid‐course information for the planning of the second stage, thus meeting practical requirements when performing clinical phase II trials in oncology. Copyright © 2012 John Wiley & Sons, Ltd.     

生产还是消费——中国股市生产资本资产定价模型实证检验

生产资本资产定价模型从企业利润最大化角度出发,推出资产的均衡价格.相较于消费资本资产定价模型,生产资本资产定价模型能更好的满足信息完全和决策者理性的假设条件.本文从生产资本资产定价模型出发,利用现值模型将生产的系统性风险因子,即生产的贝塔因子分解为现金流贝塔和折现率贝塔,并采用社会总投资和股市数据进行实证检验.本文发现生产-现金流贝塔是中国股市的重要定价因子,可较好地解释股权溢价的截面差异.相比之下,消费资本资产定价模型对不同资产之间风险溢价的解释能力较弱.     

胡尖山地区长 6、长 4+5 储层有利区预测

摘要：以胡尖山油田长 6、长 4+5 油藏为例，综合应用地质资料、岩芯分析资料、测井资料以及试油资料，开展了长 6和长 4+5 油藏小层划分和对比、单井相分析，建立测井相识别模式，编制小层沉积相平面展布图，进而分析沉积相演化规律；探讨储层砂体展布以及物性分布规律，从而深入认识研究区的储层特征。在此基础上对储层进行流动单元的划分，然后结合试油资料对胡尖山油田长 6、长 4+5 油藏的储层进行有利区域的预测，为油田待开发区域的合理建产开发提供了理论指导     

A simulation study of methods for selecting subgroup‐specific doses in phase 1 trials

Patient heterogeneity may complicate dose‐finding in phase 1 clinical trials if the dose‐toxicity curves differ between subgroups. Conducting separate trials within subgroups may lead to infeasibly small sample sizes in subgroups having low prevalence. Alternatively,it is not obvious how to conduct a single trial while accounting for heterogeneity. To address this problem,we consider a generalization of the continual reassessment method on the basis of a hierarchical Bayesian dose‐toxicity model that borrows strength between subgroups under the assumption that the subgroups are exchangeable. We evaluate a design using this model that includes subgroup‐specific dose selection and safety rules. A simulation study is presented that includes comparison of this method to 3 alternative approaches,on the basis of nonhierarchical models,that make different types of assumptions about within‐subgroup dose‐toxicity curves. The simulations show that the hierarchical model‐based method is recommended in settings where the dose‐toxicity curves are exchangeable between subgroups. We present practical guidelines for application and provide computer programs for trial simulation and conduct.     

Deactivating the Buttons: Integrating Radical Exposure Tapping with a Family Therapy Framework

The purpose of this paper is to describe and illustrate with case examples a brief intervention termed Radical Exposure Tapping (RET). RET can be integrated with family therapy to address stuck points where the therapy is hindered by a family member's affective block, an intense and unchangeable emotional reactivity to a specific trigger. RET draws from the methodology of Eye Movement Desensitization and Reprocessing (EMDR) and combines it with the tapping sequence of the Emotional Freedom Technique (EFT) to produce an intervention that is more flexible than EMDR, provides greater rigor than using the EFT technique alone and can be effective in a single session within the context of family therapy. The paper puts this work into context by first over viewing definitions of trauma and Post‐Traumatic Stress Disorder, arguing that family members' emotional reactivity may be a symptom of PTSD even when they would not qualify for the diagnosis because they had not experienced a life threatening event.     

现金流量表分析切合点的现实思考

现金流量袁是财务报告的三张基本报表之一，通过现金流量表，可以概括反映经营活动、投资活动和筹资活动对企业现金流入流出的影响。对现金流量表的分析，既要掌握该表的结构及特点，分析其内部构成，又要结合固定付现费用的支付能力、企业资金来源比例和再投资能力进行综合分析，以求全面、客观地评价企业的财务状况和经营业绩．从而帮助投资者与债权人是否进行投资提供决策依据。     

Bayesian elastic net single index quantile regression

Single index model conditional quantile regression is proposed in order to overcome the dimensionality problem in nonparametric quantile regression. In the proposed method, the Bayesian elastic net is suggested for single index quantile regression for estimation and variables selection. The Gaussian process prior is considered for unknown link function and a Gibbs sampler algorithm is adopted for posterior inference. The results of the simulation studies and numerical example indicate that our propose method, BENSIQReg, offers substantial improvements over two existing methods, SIQReg and BSIQReg. The BENSIQReg has consistently show a good convergent property, has the least value of median of mean absolute deviations and smallest standard deviations, compared to the other two methods.